Where to order Generic Desyrel(Trazodone)?

How to buy (order) Desyrel/Trazodone online.

Generic Desyrel (Trazodone)

This medication is an antidepressant approved for the treatment of depression. However, your doctor may use these medications for other problems as well. For example, because Trazodone will make you sleepy, your doctor may prescribe it for you to take before bed for insomnia. When Desyrel is prescribed for sleep, it should only be taken at bedtime. You may begin to feel the effects within a week, but to get the full effect of this medication, you need to take it for two to four weeks.

MEDICATION USE

• Take the medicine only as prescribed by your doctor, and do not miss a single dose. Do not take it more often than prescribed and also do not increase the dose without your doctor’s approval. If you miss a dose, take it as soon as possible, but if it is close to your next dose, skip it and continue to take the medicine as prescribed by your doctor.
• Do not suddenly stop taking the medicine yourself, only as directed by your doctor. To stop taking these medications, you need to gradually reduce the dose until they stop completely.
• Keep your antidepressant in a safe place away from children, heat, light and humidity.

How to buy (order) Generic Desyrel/Trazodone?

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Antidepressant, thiazolopyridine derivative. It also has thymoleptic, anxiolytic, sedative and muscle relaxant effects. It has a high affinity for certain subtypes of serotonin receptors and inhibits the reuptake of serotonin; the neuronal uptake of norepinephrine and dopamine has little effect.

Does not have an anticholinergic effect, does not inhibit MAO, does not change body weight. Eliminates both mental (affective tension, irritability, fear, insomnia) and somatic manifestations of anxiety (palpitations, headache, myalgia, frequent urination, increased sweating). Increases the depth and duration of sleep in patients with depression, restores its physiological structure.

Reduces pathological craving for ethanol. It is effective for withdrawal symptoms in patients with drug dependence on anxiolytic drugs derived from benzodiazepines, eliminates anxiety and depression and sleep disorders (during the period of remission, benzodiazepines can be completely replaced by trazodone). Not addictive. Helps restore libido and potency.

The therapeutic effect in 50% of patients is observed after 3-7 days, in 25% – after 2-4 weeks.

After oral administration, absorption from the gastrointestinal tract is high. The time to reach Cmax in blood plasma is 1-2 hours. Taking trazodone during or immediately after a meal increases absorption, reduces Cmax and increases the time to reach it.

Penetrates histohematic barriers, including the BBB. Penetrates into tissues and liquids (bile, saliva, breast milk). Plasma protein binding – 89-95%.

Metabolized in the liver by hydroxylation. The metabolism of the drug involves isoenzymes CYP3A4, CYP3A5 and CYP3A7.

T1/2 in the α-phase is 3-6 hours, in the β-phase – 5-9 hours. Excreted by the kidneys – 75% in the form of inactive metabolites within 98 hours after administration; 20% – with bile.

Indications for the active substance TRAZODONE

Various forms of depression (endogenous, psychotic, neurotic, somatogenic), incl. with severe anxiety, including at least 4 of the following signs: sleep disturbances, appetite disorders, psychomotor agitation or retardation, decreased interest in others, decreased sexual activity, feelings of guilt, increased fatigue, slowed thinking, decreased ability to concentrate, suicidal attempts/thoughts ; bulimia, kleptomania, anxiety, phobias. Benzodiazepine drug dependence; acute alcohol withdrawal syndrome. Decreased libido, impotence. Prevention of migraine attacks.

Dosage regimen

The initial daily dose is 150-200 mg (in 3 divided doses). For mild forms of depression, the average maintenance dose is 150 mg/day; for moderate and severe forms – 300 mg/day. If necessary, the dose can be increased to 600 mg/day. It is recommended to take the bulk of the daily dose before bedtime.

Side effect

From the central nervous system and peripheral nervous system: drowsiness, increased fatigue, dizziness, insomnia, headache, agitation, myalgia, impaired coordination of movements, paresthesia, disorientation, blackout, tremor.

From the cardiovascular system: arrhythmia, conduction disturbances, bradycardia, ventricular fibrillation, decreased blood pressure, orthostatic hypotension, fainting.

From the digestive system: nausea, vomiting, diarrhea, dryness and bitterness in the mouth.

On the part of the organ of vision: blurred vision, eye irritation.

From the hematopoietic system: leukopenia, neutropenia (usually minor).

Other: nasal congestion, priapism with subsequent impotence, allergic reactions.

Contraindications for use

1. Ventricular arrhythmia, tachycardia, myocardial infarction (early recovery period), history of priapism, pregnancy, lactation, hypersensitivity to trazodone.
2. Use during pregnancy and breastfeeding
3. Use during pregnancy and lactation is contraindicated.
4. Use for liver dysfunction
5. C Use with caution in case of liver failure.
6. Use for renal impairment
7. Use with caution in renal failure.

Use in children

Use with caution in children and adolescents under 18 years of age.

Special instructions

Use with caution in case of heart disease, arterial hypotension, arterial hypertension, renal and/or liver failure, in children and adolescents under the age of 18 years.

Should not be used simultaneously with MAO inhibitors.

Drug interactions

A case of arrhythmia developing with simultaneous use of trazodone and amiodarone has been described.

A case has been described of a moderately pronounced decrease in the anticoagulant effect of warfarin when used simultaneously with trazodone.

With simultaneous use, it is possible to increase the concentration of digoxin in the blood plasma and develop symptoms of intoxication.

When used simultaneously with carbamazepine, a case of increased concentrations of carbamazepine in the blood plasma has been described.

When used simultaneously with lithium salts, tremor and reversible symptoms of neurotoxicity are possible.

When taking pseudoephedrine during therapy with trazodone, a case of developing anxiety, panic, blackout, and depersonalization has been described.

When used simultaneously with thioridazine, it is possible to increase the concentration of trazodone in the blood plasma; with tryptophan – a case of the development of anorexia, psychosis, hypomania is described; with phenytoin – a case of increased side effects of phenytoin has been described; with fluoxetine – increased side effects are possible; with chlorpromazine, trifluoperazine – arterial hypotension may develop.

When used simultaneously with ethanol, the inhibitory effect on the central nervous system increases.